A SECRET WEAPON FOR PKRRATING

The activated enzyme then phosphorylates its important substrate, the translational initiation component eIF2α. The resulting translational arrest blocks viral replication. PKR belongs to your conserved family of 4 protein kinases (PKR, PERK, GCN2, HRI) that each one phosphorylate eIF2α in reaction to different stimuli12, triggering the built-in